Format

Send to

Choose Destination
Curr Opin Plant Biol. 2006 Oct;9(5):470-7. Epub 2006 Aug 4.

Switching the flip: protein phosphatase roles in signaling pathways.

Author information

1
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA. alison_delong@brown.edu <alison_delong@brown.edu>

Abstract

Protein phosphatases are the obligate partners of protein kinases in cellular control circuitry. Several specific roles of phosphatases have been revealed in plant systems through recent work capitalizing on functional genomics, interaction screens and activation-tagging approaches. Historically, the redundancy of genes that encode phosphatase functions has impeded genetic analysis in plant systems, and relatively few elucidated signaling pathways include protein phosphatases that have clearly defined substrates. Functional genomics, interaction and suppression screens, activation tagging and phosphoproteomics now hold great promise for identifying phosphatases that are active in signaling and regulation, and for revealing their in vivo substrates. This level of analysis will be essential for a full understanding of the effects of reversible protein phosphorylation in modulating and integrating cellular activities.

PMID:
16890477
DOI:
10.1016/j.pbi.2006.07.015
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center