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Trends Biochem Sci. 2006 Sep;31(9):516-25. Epub 2006 Aug 4.

Themes in ssDNA recognition by telomere-end protection proteins.

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1
Department of Chemistry and Biochemistry, University of Colorado-Boulder, UCB 215, Boulder, CO 80309-0215, USA.

Abstract

The ends of eukaryotic linear chromosomes are unique structures that require special management by the cell. If left unattended, the ends are inappropriately processed, leading to genomic instability and problems with proliferation. Telomeres are specialized nucleoprotein structures that restore chromosome stability by protecting and maintaining chromosome ends. Proper telomere function is facilitated, in part, by the telomere-end protection (TEP) family of proteins, which targets the 3' single-stranded (ss) overhang region of the telomere via a specialized ssDNA-binding domain (DBD). With the recent availability of the structures of these DBDs, the ssDNA-binding characteristics of TEP proteins can be compared and the common underlying mechanisms of ssDNA recognition identified, thus providing insights into telomere function.

PMID:
16890443
DOI:
10.1016/j.tibs.2006.07.004
[Indexed for MEDLINE]
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