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Bioorg Med Chem Lett. 2006 Oct 15;16(20):5384-8. Epub 2006 Aug 4.

Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.

Author information

1
Dipartimento Farmaco Chimico Tecnologico, Università di Siena, via Aldo Moro, 53100 Siena, Italy.

Abstract

A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.

PMID:
16890433
DOI:
10.1016/j.bmcl.2006.07.060
[Indexed for MEDLINE]

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