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Brain Res. 2006 Sep 13;1109(1):93-107. Epub 2006 Aug 4.

Neuroanatomical localization of an internal clock: a functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems.

Author information

1
Department of Psychology and Neuroscience, Duke University, 572 Research Drive, Genome Sciences Research Building II-Box 91050, Durham, NC 27708, USA. meck@psych.duke.edu

Abstract

The effects of selective dopamine (DA) depleting lesions with 6-hydroxydopamine microinjection into the SN, CPu, and NAS, as well as radiofrequency lesions of the CPu on the performance characteristics of rats trained on a single-valued 20-s peak-interval (PI) timing procedure or a double-valued 10-s and 60-s PI procedure were evaluated. A double dissociation in the performance of duration discriminations was found. Rats with CPu lesions were unable to exhibit temporal control of their behavior suggesting complete insensitivity to signal duration but were able to show discrimination of the relative reward value of a signal by differentially modifying their response rates appropriately. In contrast, rats with NAS lesions were able to exhibit temporal control of their behavior by differentially modifying their response rates as a function of signal duration(s), suggesting no impairment of sensitivity to signal duration, but were unable to show discrimination of the relative reward value of a signal.

PMID:
16890210
DOI:
10.1016/j.brainres.2006.06.031
[Indexed for MEDLINE]

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