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Mutat Res. 1990 Feb;228(2):171-6.

The effects of a range of anti-cancer drugs in the white-ivory somatic mutation test in Drosophila.

Author information

1
Department of Biology, University of York, Heslington, Great Britain.

Abstract

The white-ivory test is based upon the reversion of the X-linked, recessive eye-colour mutation white-ivory to wild-type. Somatic reversion of white-ivory results in clones of red facets in the white-ivory eyes of eclosing adult flies. 4 anti-cancer drugs, bleomycin, adriamycin, mitoxantrone and cyclophosphamide were found to significantly increase the white-ivory reversion frequency whereas cytosine arabinoside, methotrexate and vincristine did not give positive results.

PMID:
1689004
DOI:
10.1016/0027-5107(90)90073-d
[Indexed for MEDLINE]

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