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Curr Opin Drug Discov Devel. 2006 Jul;9(4):471-82.

Advances in cathepsin S inhibitor design.

Author information

1
Gilead Sciences Inc, 344 Lakeside Drive, Foster City, CA 94404, USA. john.link@gilead.com

Abstract

Cathepsin S is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases. This review focuses on advances in cathepsin S inhibitor utility and design since January of 2004.

PMID:
16889230
[Indexed for MEDLINE]

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