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Ophthalmic Res. 2006;38(5):251-4. Epub 2006 Jul 28.

Targeting pericytes diminishes neovascularization in orthotopic uveal melanoma in nerve/glial antigen 2 proteoglycan knockout mouse.

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  • 1La Jolla Institute for Molecular Medicine, San Diego, Calif, USA. ozerdem@ljimm.org

Abstract

In this investigation, we explored whether knockout of nerve/glial antigen 2 (NG2), a pericyte component, inhibited neovascularization and growth of uveal melanoma xenografts. For this, we used multichannel laser scanning confocal microscopy and quantitative image analysis. Orthotopic human uveal melanoma (OCM-1A) xenografts were induced in NG2 knockout and wild-type mice, which were immunosuppressed with cyclosporin A. Inhibition of pericytes through NG2 proteoglycan decreased neovascularization and tumor end volume, rendering pericytes and NG2 proteoglycan potential cellular and molecular therapeutic targets in uveal melanoma.

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PMID:
16888406
PMCID:
PMC1586067
DOI:
10.1159/000094833
[PubMed - indexed for MEDLINE]
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