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Aliment Pharmacol Ther. 2006 Aug 1;24(3):535-9.

Coexistence between colorectal cancer/adenoma and coronary artery disease: results from 1382 patients.

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1
Division of Gastroenterology and Hepatology, Department of Medicine, The University of Hongkong, Hong Kong, China. aoochan@hku.hk

Abstract

BACKGROUND:

Common risk factors exist in colorectal neoplasia (cancer or adenoma) and coronary artery disease.

AIM:

To investigate in a retrospective study if there is coexistence of the two events in patients > OR =50 years.

METHODS:

Computer data on colonoscopies performed on symptomatic patients, the corresponding medical record and colonic histology in 1997-2000 were retrieved. History of coronary artery disease was recorded. To adjust for the factors of age and sex, bivariate logistic regression analysis was used to test for coexistence.

RESULTS:

1382 patients were recruited. Colorectal neoplasia and history of coronary artery disease were present in 27% (373) and 12% (167) of patients, respectively. The mean age of patients was older in colorectal neoplasia+ (75 +/- 11 vs. 69 +/- 13 years, P < 0.0001) and in coronary artery disease+ (79 +/- 9 vs. 69 +/- 12 years, P < 0.0001) patients. Male was the predominant sex in colorectal neoplasia+: 33% vs. 22% (P < 0.0001), but not in coronary artery disease+ (P = 0.29). Colorectal neoplasia+ patients were more likely to have coronary artery disease+ [21.2% (79/373) vs. 8.8% (89/1098) (P < 0.0001)]. Bivariate logistic regression analysis showed strong association between the two events (OR: 2.12, 95% CI: 1.5, 3.0).

CONCLUSION:

There is strong coexistence of colorectal neoplasia and coronary artery disease, probably due to exposure to common risk factors.

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