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J Immunol. 1990 Feb 1;144(3):960-3.

Murine IL-4 antagonizes the protective effects of IFN on virus-mediated lysis of murine L929 fibroblast cells.

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1
Institut für klinische Mikrobiologie der Universität, Erlangen-Nürnberg, FRG.

Abstract

IFN-alpha, -beta, and -gamma protect murine fibroblasts from lysis by vesicular stomatitis virus. In this report we show that culture supernatants derived from a Th cell clone of the TH2-type completely block the protective effects of the IFN. The active component in inhibiting IFN is identified to be IL-4. rIL-4 has similar effects as the T cell supernatant.

PMID:
1688593
[Indexed for MEDLINE]
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