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J Bacteriol. 2006 Aug;188(16):6026-33.

Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa.

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1
Département de Microbiologie Fondamentale, Université de Lausanne, Building Biophore, CH-1015 Lausanne, Switzerland.

Abstract

In Pseudomonas aeruginosa, the GacS/GacA two-component system positively controls the quorum-sensing machinery and the expression of extracellular products via two small regulatory RNAs, RsmY and RsmZ. An rsmY rsmZ double mutant and a gacA mutant were similarly impaired in the synthesis of the quorum-sensing signal N-butanoyl-homoserine lactone, the disulfide bond-forming enzyme DsbA, and the exoproducts hydrogen cyanide, pyocyanin, elastase, chitinase (ChiC), and chitin-binding protein (CbpD). Both mutants showed increased swarming ability, azurin release, and early biofilm development.

PMID:
16885472
PMCID:
PMC1540078
DOI:
10.1128/JB.00409-06
[Indexed for MEDLINE]
Free PMC Article
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