Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Hypertens Rep. 2006 Aug;8(4):298-303.

Endothelin, the kidney, and hypertension.

Author information

  • 1Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, 39216-4505, USA. jgranger@physiology.umsmed.edu

Abstract

The kidneys play a central role in the long-term regulation of blood pressure and in the pathogenesis of hypertension. A common defect that has been found in all forms of hypertension examined to date is a hypertensive shift in the pressure-natriuresis relationship. A major objective of this brief review is to highlight some of the recent advances in our understanding of the mechanisms whereby the renal endothelin system, via endothelin type A- and endothelin type B-receptor activation, modulates renal pressure-natriuresis and blood pressure regulation under normal physiologic conditions and in certain forms of hypertension.

PMID:
16884660
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center