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Nat Rev Drug Discov. 2006 Aug;5(8):635-40. Epub 2006 Apr 13.

Case histories, magic bullets and the state of drug discovery.

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1
jurgendrews@comcast.net

Abstract

The case histories of five modern drugs are taken as a basis for reflection on the state of drug discovery. Two issues intimately associated with drug research are highlighted: the nature of the intellectual process leading to new discoveries; and the possibility that the principle of selective efficacy, which has guided drug research from its beginnings, might need modification, at least in some areas of pharmacotherapy.

PMID:
16883301
DOI:
10.1038/nrd2084
[Indexed for MEDLINE]
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