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J Antimicrob Chemother. 2006 Oct;58(4):778-83. Epub 2006 Jul 30.

In vitro activity of a new antibacterial rhodanine derivative against Staphylococcus epidermidis biofilms.

Author information

1
CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Santé, Faculté de Pharmacie Montpellier, France.

Abstract

OBJECTIVES:

Staphylococcus epidermidis biofilms form at the surface of implants and prostheses and are responsible for the failure of many antibiotic therapies. Only a few antibiotics are relatively active against biofilms, and rifampicin, a transcription inhibitor, is among the most effective molecules for treating biofilm-related infections. Having recently selected a new potential transcription inhibitor, we attempted to evaluate its efficacy against S. epidermidis biofilms.

METHODS:

Biofilm-forming S. epidermidis strains were grown planktonically or as biofilms and their susceptibility to this transcription inhibitor was compared with reference antibiotics with different mechanisms of action.

CONCLUSIONS:

Our results demonstrate that this new molecule is active; its effects are fast and kinetically related to those of rifampicin, but unlike rifampicin it does not select for resistant bacteria.

PMID:
16880176
DOI:
10.1093/jac/dkl314
[Indexed for MEDLINE]

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