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Dig Liver Dis. 2006 Oct;38(10):732-6. Epub 2006 Jul 31.

Intestinal permeability in patients with adverse reactions to food.

Author information

1
Department of Internal Medicine, Immunology and Infectious Diseases (MIDIM), University of Bari Medical School, Policlinico, Piazza G. Cesare n 11, 70124 Bari, Italy. mt.ventura@allergy.uniba.it

Abstract

BACKGROUND:

An abnormal intestinal permeability could contribute to establish an altered sensitivity to food-allergen.

AIM:

To evaluate the intestinal permeability in subjects with adverse reactions to food on allergen-free diet.

SUBJECTS:

Twenty-one patients with food allergy and 20 with food hypersensitivity on allergen-free diet were enrolled and divided in four groups according to the seriousness of their referred clinical symptoms when they were on a free diet.

METHODS:

Intestinal permeability was evaluated by Lactulose/Mannitol ratio urinary detection determined by anion-exchange chromatography.

RESULTS:

Statistically significant different Lactulose/Mannitol ratio was evidenced in subjects with food allergy (p=0.003) or hypersensitivity (p=0.0008) compared to control patients. The correlation between Lactulose/Mannitol ratio and the seriousness of clinical symptoms, by using Spearman test, was statistically significant for food allergy (p=0.0195) and hypersensitivity (p=0.005) patients.

CONCLUSIONS:

The present data demonstrate that impaired intestinal permeability, measured in our conditions, is present in all subjects with adverse reactions to food. In addition, for the first time, we report a statistically significant association between the severity of referred clinical symptoms and the increasing of Intestinal Permeability Index. These data reveal that intestinal permeability is not strictly dependent on IgE-mediated processes but could better be related to other mechanisms involved in early food sensitisation, as breast-feeding, or microbial environment that influence the development of oral tolerance in early infancy.

PMID:
16880015
DOI:
10.1016/j.dld.2006.06.012
[Indexed for MEDLINE]
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