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Neuropsychologia. 2006;44(14):2836-45. Epub 2006 Aug 1.

How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations.

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MR Research Center, Cognitive Neurophysiology, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.


The default mode of brain function hypothesis and the presence of spontaneous intrinsic low-frequency signal fluctuations during rest have recently attracted attention in the neuroscience community. In this study we asked two questions: First, is it possible to attenuate intrinsic activity in the self-referential, default mode of brain function by directing the brains resources to a goal-oriented and attention-demanding task? Second, what effect does a sustained attention-demanding overt task performance have on the two intrinsically active networks in the brain, those being the task-negative, default-mode and the anticorrelated, task-positive network? We used functional magnetic resonance imaging to monitor spontaneous intrinsic activity during rest and sustained performance of a sequential two-back working memory task. We compared intrinsic activity during rest and the two-back task to the signal increases and decreases observed in an epoch-related version of the working memory task. Our results show that spontaneous intrinsic activity in the default-mode network is not extinguished but rather attenuated during performance of the working memory task. Moreover, we show that the intrinsic activity in the task-positive network is reorganized in response to the working memory task. The results presented here complements earlier work that have shown that task-induced signal deactivations in the default-mode regions is modulated by cognitive load to also show that intrinsic, spontaneous signal fluctuations in the default-mode regions persist and reorganize in response to changes in external work load.

[Indexed for MEDLINE]

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