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Neurosci Lett. 1991 Dec 9;133(2):211-4.

Inhibitory effect of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on the micturition reflex in rat.

Author information

1
Department of Physiology, School of Medicine, Showa University, Tokyo, Japan.

Abstract

The effect of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), an alpha-amino-hydroxy-5-methyl-4-isoxazole propionate (AMPA) glutamate receptor antagonist, on bladder contractions was examined under isometric conditions in urethane anesthetized rats. Intravenous administration of CNQX (33 ng-50 micrograms/kg) inhibited or abolished bladder contraction. Before complete inhibition, the frequency of bladder contractions was reduced without altering the amplitude or duration. Intrathecal administration of CNQX (2 ng/kg-11 micrograms/kg) similarly inhibited bladder contractions. In contrast, CNQX did not affect bladder contractions in chronically spinalized animals (6.7 ng/kg-400 micrograms/kg i.v.), or contractions evoked by stimulation of the decentralized pelvic nerve (1-100 micrograms/kg i.v.).

PMID:
1687757
DOI:
10.1016/0304-3940(91)90572-b
[Indexed for MEDLINE]

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