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J Control Release. 2006 Sep 12;114(3):343-7. Epub 2006 Jun 23.

PEG-modified gold nanorods with a stealth character for in vivo applications.

Author information

1
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. niidome-tcm@mbox.nc.kyushu-u.ac.jp <niidome-tcm@mbox.nc.kyushu-u.ac.jp>

Abstract

Gold nanorods prepared in hexadecyltrimethylammonium bromide (CTAB) solution are expected to provide novel materials for photothermal therapy and photo-controlled drug delivery systems. Since gold nanorods stabilized with CTAB show strong cytotoxicity, we developed a technique to modify these with polyethyleneglycol (PEG) for medical applications. PEG-modification was achieved by adding mPEG-SH in the CTAB solution, then, excess CTAB was removed by dialysis. PEG-modified gold nanoparticles showed a nearly neutral surface, and had little cytotoxicity in vitro. Following intravenous injection into mice, 54% of injected PEG-modified gold nanoparticles were found in blood at 0.5 h after intravenous injection, whereas most of gold was detected in the liver in the case of original gold nanorods stabilized with CTAB.

PMID:
16876898
DOI:
10.1016/j.jconrel.2006.06.017
[Indexed for MEDLINE]

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