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Prog Neuropsychopharmacol Biol Psychiatry. 2006 Dec 30;30(8):1529-31. Epub 2006 Jul 28.

Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism.

Author information

1
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan. hashimoto@faculty.chiba-u.jp

Erratum in

  • Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):592.

Abstract

BACKGROUND:

The precise mechanisms underlying the pathophysiology of autism are currently unknown. Given the key role of brain-derived neurotrophic factor (BDNF) in brain development, we hypothesized that BDNF may play a role in the pathophysiology of autism. In this study, we studied whether serum levels of BDNF are altered in patients with autism.

METHODS:

We measured serum levels of BDNF in 18 adult male patients with autism and 18 age-matched healthy male control subjects.

RESULTS:

The serum levels of BDNF in patients with autism (25.6+/-2.15 ng/ml (mean+/-S.D.)) were significantly (z = -4.42, p < 0.001) lower than those of normal controls (61.6+/-10.9 ng/ml (mean+/-S.D.)). Nevertheless, we found no correlations between BDNF levels and clinical variables in autistic patients.

CONCLUSIONS:

This study suggests that reduced BDNF levels may play a role in the pathophysiology of autism.

PMID:
16876305
DOI:
10.1016/j.pnpbp.2006.06.018
[Indexed for MEDLINE]
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