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Autophagy. 2006 Apr-Jun;2(2):80-4. Epub 2006 Apr 29.

Autophagy, mitochondrial quality control, and oncogenesis.

Author information

1
Pharmacology Department and the Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA. jinsh@umdnj.edu

Abstract

Cancer is a disease associated with aging. More than 80% of human cancers are diagnosed in people aged 55 years or older. Autophagy has recently been demonstrated to be a novel mechanism of tumor suppression. Interestingly, autophagy also plays an important role in the control of aging. Here we summarize the genetic studies of autophagy in tumorigenesis and aging, and propose that autophagy may suppress tumor development and prevent aging through a common mechanism involving mitochondrial surveillance.

PMID:
16874075
DOI:
10.4161/auto.2.2.2460
[Indexed for MEDLINE]

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