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Biofactors. 2005;25(1-4):137-45.

Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failure.

Author information

1
Lancisi Heart Institute, Department of Cardiology and Cardiac Surgery, Ancona, Italy. r.belardinelli@fastnet.it

Abstract

BACKGROUND:

There is evidence that plasma CoQ(10) levels decrease in patients with advanced chronic heart failure (CHF).

OBJECTIVE:

To investigate whether oral CoQ(10) supplementation could improve cardiocirculatory efficiency in patients with CHF.

METHODS:

We studied 21 patients in NYHA class II and III (18M, 3W, mean age 59 +/- 9 years) with stable CHF secondary to ischemic heart disease (ejection fraction 37 +/- 7%), using a double-blind, placebo-controlled cross-over design. Patients were assigned to oral CoQ(10) (100 mg tid) and to placebo for 4 weeks, respectively.

RESULTS:

CoQ(10) supplementation resulted in a threefold increase in plasma CoQ(10) level (P < 0.0001 vs placebo). Systolic wall thickening score index (SWTI) was improved both at rest and peak dobutamine stress echo after CoQ(10) supplementation (+12.1 and 15.6%, respectively, P < 0.05 vs placebo). Left ventricular ejection fraction improved significantly also at peak dobutamine (15% from study entry P < 0.0001) in relation to a decrease in LV end-systolic volume index (from 57 +/- 7 mL/m(2) to 45 mL/m(2), P < 0.001). Improvement in the contractile response was more evident among initially akinetic (+33%) and hypokinetic (+25%) segments than dyskinetic ones (+6%). Improvement in SWTI was correlated with changes in plasma CoQ(10) levels (r = -0.52, P < 0.005). Peak VO(2) was also improved after CoQ(10) as compared with placebo (+13%, <0.005). No side effects were reported with CoQ(10).

CONCLUSIONS:

Oral CoQ(10) improves LV contractility in CHF without any side effects. This improvement is associated with an enhanced functional capacity.

PMID:
16873938
[Indexed for MEDLINE]
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