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Science. 2006 Jul 28;313(5786):536-40.

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

Author information

1
Department of Biology, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA.

Abstract

Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment.

PMID:
16873667
DOI:
10.1126/science.1123432
[Indexed for MEDLINE]
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