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Cell. 2006 Jul 28;126(2):253-6.

FOXP3 and NFAT: partners in tolerance.

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1
Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA. aruden@u.washington.edu

Abstract

Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.

PMID:
16873058
DOI:
10.1016/j.cell.2006.07.005
[Indexed for MEDLINE]
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