Complete remission in a pancytopenic HIV negative, HHV-8 positive patient with multicentric Castleman's disease induced with anti-CD20

Clin Transl Oncol. 2006 Jul;8(7):540-1. doi: 10.1007/s12094-006-0056-2.

Abstract

A 75-year-old woman was diagnosed of MCD plasma cell (PC) variant with B symptoms. Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present. Actually patient is free of disease. This is the first complete response of MCD published, VIH negative, induced with anti CD20.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Murine-Derived
  • Antigens, CD20
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Castleman Disease / complications
  • Castleman Disease / drug therapy*
  • Castleman Disease / immunology
  • Female
  • HIV Seronegativity
  • Herpesviridae Infections / complications
  • Herpesvirus 8, Human
  • Humans
  • Pancytopenia / complications
  • Remission Induction
  • Rituximab

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Antigens, CD20
  • Rituximab