Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2006 Oct 1;16(19):5183-9. Epub 2006 Jul 25.

Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease.

Author information

1
Department of Chemistry, Hawaii Biotech, Inc., 99-193 Aiea Heights Dr., Suite 200, Aiea, 96701, USA. gjiao@hibiotech.com

Abstract

A series of mono-, di-, and tri-guanidinylated derivatives of neamine were prepared via selective guanidinylation of neamine. These molecules represent a novel scaffold as inhibitors of anthrax lethal factor zinc metalloprotease. Methods for the synthesis of these compounds are described, and structure-activity relationships among the series are analyzed. In addition, initial findings regarding the mechanism of LF inhibition for these molecules are presented.

PMID:
16870442
DOI:
10.1016/j.bmcl.2006.07.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center