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Nat Rev Immunol. 2006 Aug;6(8):618-23. doi: 10.1038/nri1866.

The descent of memory T-cell subsets.

Author information

1
University of Connecticut Health Center, Department of Immunology, Farmington, Connecticut 06030, USA. llefranc@neuron.uchc.edu

Abstract

The immune system has evolved by continuously increasing its complexity to provide the host with an advantage over infectious agents. The development of immunological memory engenders long-lasting protection and lengthens the lifespan of the host. The generation of subsets of memory T cells with distinct homing and functional properties increases our defensive capabilities. However, the developmental relationship of memory T-cell subsets is a matter of debate. In this Opinion article, in light of recent developments, we suggest that it is probable that two distinct lineages comprise the memory CD8+ T-cell population generated in response to infection.

PMID:
16868553
DOI:
10.1038/nri1866
[Indexed for MEDLINE]

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