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AIDS. 2006 Aug 1;20(12):1673-5.

DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children.

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Department of Developmental and Reproductive Sciences, University of Trieste, Trieste, Italy.


In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of northeastern Brazilian children in order to assess their role in HIV-1 infection. Our results allowed us to hypothesize that the SNPs located in the 5' UTR of the DEFB1 gene can be employed as a marker of risk for HIV-1 infection.

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