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Physiology (Bethesda). 2006 Aug;21:242-9.

Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier.

Author information

1
Département de Réponse et Dynamique Cellulaires, CEA-Grenoble, Laboratoire de Biochimie et Biophysique des Systèmes Intégrés, UMR 5092 CEA-CNRS-Université Joseph Fourier, Grenoble, France.

Abstract

In providing the cell with ATP generated by oxidative phosphorylation, the mitochondrial ADP/ATP carrier plays a central role in aerobic eukaryotic cells. Combining biochemical, genetic, and structural approaches contributes to understanding the molecular mechanism of this essential transport system, the dysfunction of which is implicated in neuromuscular diseases.

PMID:
16868313
DOI:
10.1152/physiol.00005.2006
[Indexed for MEDLINE]
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