Format

Send to

Choose Destination
J Clin Endocrinol Metab. 2006 Oct;91(10):3941-6. Epub 2006 Jul 25.

Effect of raloxifene on bone mineral density in premenopausal women at increased risk of breast cancer.

Author information

1
Medical Oncology Clinical Research Unit, National Cancer Institute, Building 10, Room 12N226, 9000 Wisconsin Avenue, Bethesda, MD 20892, USA. engwongj@mail.nih.gov

Abstract

CONTEXT:

Raloxifene is a promising breast cancer prevention agent in postmenopausal women at increased risk for breast cancer. The effects of raloxifene in premenopausal women are unknown.

OBJECTIVE:

We evaluated the effect of raloxifene in premenopausal women at increased risk for breast cancer on bone mineral density (BMD).

DESIGN:

This was a phase II clinical trial.

SETTING:

This study was conducted at an academic medical center.

PARTICIPANTS:

Thirty-seven premenopausal women at increased risk for breast cancer enrolled in the trial. Thirty subjects began treatment and 27 were evaluable.

INTERVENTION:

Raloxifene (60 mg daily) and elemental calcium (500 mg daily) were given for 2 yr. Subjects were followed up off medications for 1 yr.

MAIN OUTCOME MEASURE:

The primary end point was the intrasubject percent change in BMD at 1 yr measured by dual-energy x-ray absorptiometry.

RESULTS:

The mean baseline lumbar spine density was 1.027 g/cm(2). Lumbar spine density decreased 2.3% at 1 yr (P < 0.00001) and 3.5% at 2 yr (P < .00001). Percent change from yr 2 to 3 was +1.4%. The mean baseline total hip bone density was 0.905 g/cm(2). Total hip density decreased 0.3% at 1 yr and 1.0% at 2 yr (P = 0.033). Percent change from yr 2 to 3 was +1.7%.

CONCLUSIONS:

Raloxifene use is associated with a decrease in BMD in premenopausal women at increased risk for breast cancer. The clinical significance of this decrease is unknown and is attenuated with stopping raloxifene.

Comment in

PMID:
16868059
DOI:
10.1210/jc.2005-2827
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center