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J Am Chem Soc. 2006 Aug 2;128(30):9963-70.

Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.

Author information

1
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Abstract

We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.

PMID:
16866556
PMCID:
PMC4692383
DOI:
10.1021/ja062791w
[Indexed for MEDLINE]
Free PMC Article

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