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Int Arch Allergy Immunol. 2006;141(2):119-29. Epub 2006 Jul 21.

IgE-mediated allergen presentation and blocking antibodies: regulation of T-cell activation in allergy.

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Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.


It is well established that both the production of IgE by B lymphocytes and the maturation and recruitment of eosinophils in late-phase reactions are dependent on the activation of allergen-specific type-2 T-helper cells. What is less well known is the fact that efficient activation of allergen-specific T cells upon low-dose exposure to allergens is critically dependent on IgE-mediated or -facilitated allergen presentation. In fact, changes in the level of IgE-mediated allergen presentation may account for many of the immunological effects described for specific immunotherapy or anti-IgE treatment. This review aims to summarize the current knowledge, and will discuss the clinical relevance of blocking IgG antibodies induced by specific immunotherapy and anti-IgE monoclonal antibodies that both interfere with IgE-mediated allergen presentation.

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