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Neurology. 2006 Jul 25;67(2):320-1.

RLS3: fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity.

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  • 1Department of Clinical Neurophysiology, Georg-August-University, Goettingen, Germany.


A new locus for restless legs syndrome (RLS3) was identified on chromosome 9p24-22. The authors analyzed transmission disequilibrium tests (TDTs) and affecteds-only linkage analysis in one large family of Bavarian origin, taking into account age at onset. P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp).

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