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PLoS Comput Biol. 2006 Jul 28;2(7):e96. Epub 2006 Jun 8.

Circadian rhythmicity by autocatalysis.

Author information

1
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire, USA.

Abstract

The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations.

PMID:
16863394
PMCID:
PMC1523307
DOI:
10.1371/journal.pcbi.0020096
[Indexed for MEDLINE]
Free PMC Article

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