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N Z Med J. 2006 Jul 7;119(1237):U2058.

Quetiapine and citalopram: aetiological significances in serotonin syndrome.

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Tower Hamlets Early Intervention Service, Royal London Hospital, St Clement's, 2A Bow Road, Mile End, London E3 4LL, UK.


The use of atypical antipsychotic medication is increasing, with an increase in reported side-effects. The first reported case of quetiapine and citalopram-associated serotonin syndrome is discussed with reference to a Medline, Embase, and PsycINFO literature search. The putative aetiological mechanism is supersensitivity of 5-HT(1A) receptors (quetiapine) within an environment of increased synaptic available serotonin (citalopram). The symptom profile of serotonin syndrome overlaps with neuroleptic malignant syndrome, but can be reliably differentiated using a time and toxicity scale.

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