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Nat Methods. 2006 Aug;3(8):601-3.

A unique and universal molecular barcode array.

Author information

1
Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.

Abstract

Molecular barcode arrays allow the analysis of thousands of biological samples in parallel through the use of unique 20-base-pair (bp) DNA tags. Here we present a new barcode array, which is unique among microarrays in that it includes at least five replicates of every tag feature. The use of smaller dispersed replicate features dramatically improves performance versus a single larger feature and allows the correction of previously undetectable hybridization defects.

PMID:
16862133
DOI:
10.1038/nmeth905
[Indexed for MEDLINE]

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