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World J Biol Psychiatry. 2006;7(3):158-61.

Association study of the glycogen synthase kinase-3beta gene polymorphism with prophylactic lithium response in bipolar patients.

Author information

1
Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poland. alszczep@amp.edu.pl

Abstract

A relationship between response to lithium prophylaxis and T-50C polymorphism of glycogen synthase kinase-3beta (GSK-3beta) gene was investigated in 89 bipolar patients (41 male and 48 female) who have been taking lithium for at least 5 years. The patients were delineated as excellent responders, partial responders and non-responders to lithium. The results obtained suggest that this polymorphism may not be related to the degree of prophylactic lithium response.

PMID:
16861141
DOI:
10.1080/15622970600554711
[Indexed for MEDLINE]
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