Association study of the glycogen synthase kinase-3beta gene polymorphism with prophylactic lithium response in bipolar patients

World J Biol Psychiatry. 2006;7(3):158-61. doi: 10.1080/15622970600554711.

Abstract

A relationship between response to lithium prophylaxis and T-50C polymorphism of glycogen synthase kinase-3beta (GSK-3beta) gene was investigated in 89 bipolar patients (41 male and 48 female) who have been taking lithium for at least 5 years. The patients were delineated as excellent responders, partial responders and non-responders to lithium. The results obtained suggest that this polymorphism may not be related to the degree of prophylactic lithium response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Antimanic Agents / therapeutic use*
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / genetics*
  • Female
  • Gene Frequency / genetics
  • Genotype
  • Glycogen Synthase Kinase 3 / genetics*
  • Glycogen Synthase Kinase 3 beta
  • Homozygote
  • Humans
  • Lithium Carbonate / therapeutic use*
  • Male
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Secondary Prevention
  • Statistics as Topic
  • Treatment Outcome

Substances

  • Antimanic Agents
  • Lithium Carbonate
  • GSK3B protein, human
  • Glycogen Synthase Kinase 3 beta
  • Glycogen Synthase Kinase 3