Format

Send to

Choose Destination
Brain Res. 2006 Sep 7;1108(1):216-20. Epub 2006 Jul 24.

Ethanol withdrawal is accompanied by downregulation of calcium channel alpha 1B subunit in rat inferior colliculus neurons.

Author information

1
Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20057, USA. pn@georgetown.edu

Abstract

Ethanol withdrawal enhances the current density of calcium (Ca(2+)) channels in inferior colliculus (IC) neurons. The present report shows that ethanol withdrawal markedly enhanced the susceptibility to seizures as it decreased significantly the protein levels of alpha(1B) subunit associated with N-type Ca(2+) channel in IC neurons of animals not tested for seizures. Thus, remodeling of N-type Ca(2+) channels may play an important role in neuronal hyperexcitability that leads to ethanol withdrawal seizures.

PMID:
16860782
DOI:
10.1016/j.brainres.2006.06.028
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center