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Immunity. 2006 Jul;25(1):7-9.

The polymerases for V(D)J recombination.

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1
USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, 90089-9176, USA.

Abstract

DNA transactions of a wide variety generally require three major types of enzymatic activities: nucleases, polymerases, and ligases. V(D)J recombination is no exception. In this issue, Bertocci et al. (2006) have provided new insight by generating mice deficient in one or more of the polymerases.

PMID:
16860749
DOI:
10.1016/j.immuni.2006.07.007
[Indexed for MEDLINE]
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