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C R Biol. 2006 Aug;329(8):639-52; discussion 653-5. Epub 2006 Apr 27.

[Lipodystrophic syndromes: congenital or acquired diseases of adipose tissue].

[Article in French]

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  • 1Inserm, U680, université Pierre-et-Marie-Curie, site Saint-Antoine, faculté de médecine, 27, rue Chaligny, 75571 Paris cedex 12, France.


Lipodystrophic syndromes regroup a heterogeneous group of genetic or acquired diseases. Lipodystrophy, an altered development and/or repartition of body fat, is associated with alterations of lipid and glucose metabolism with insulin resistance. Genetic forms, rare, can be generalized and recessive resulting from mutations in the seipin or AGPAT2 gene. Partial lipodystrophies are dominant and observed in patients mutated in the gene encoding PPAR-gamma or lamin A/C, a gene seen also mutated in patients with syndromes of premature aging. Acquired forms are common and regroup the highly prevalent Metabolic Syndrome, hypercorticism together with lipodystrophy related to antiretroviral treatment of HIV-infected patients.

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