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Nat Rev Neurosci. 2006 Aug;7(8):628-43.

Therapeutic interventions after spinal cord injury.

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1
Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, P.O. Box 39, 1-2 WW Ground, Denmark Hill, London SE5 8AF, UK.

Erratum in

  • Nat Rev Neurosci. 2006 Nov;7(11):902.

Abstract

Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have been tested in animal models. Many of these have reached, or are approaching, clinical trials. Here, we review these potential therapies, with an emphasis on the need for reproducible evidence of safety and efficacy. Individual therapies are unlikely to provide a panacea. Rather, we predict that combinations of strategies will lead to improvements in outcome after SCI. Basic scientific research should provide a rational basis for tailoring specific combinations of clinical therapies to different types of SCI.

PMID:
16858391
DOI:
10.1038/nrn1955
[Indexed for MEDLINE]
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