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FEBS Lett. 2006 Aug 7;580(18):4417-22. Epub 2006 Jul 13.

Some aspects of the venom proteome of the Colubridae snake Philodryas olfersii revealed from a Duvernoy's (venom) gland transcriptome.

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Centro de Biotecnologia, Instituto Butantan, Av. Vital Brazil, 1500, São Paulo, SP 05503-900, Brazil.

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  • FEBS Lett. 2006 Sep 18;580(21):5122-3.


We investigated the putative toxins of Philodryas olfersii (Colubridae), a representative of a family of snakes neglected in venom studies despite their growing medical importance. Transcriptomic data of the venom gland complemented by proteomic analysis of the gland secretion revealed the presence of major toxin classes from the Viperidae family, including serine proteases, metalloproteases, C-type lectins, Crisps, and a C-type natriuretic peptide (CNP). Interestingly, the phylogenetic analysis of the CNP precursor showed it as a linker between two related precursors found in Viperidae and Elapidae snakes. We suggest that these precursors constitute a monophyletic group derived from the vertebrate CNPs.

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