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Eur J Haematol. 2006 Aug;77(2):166-8.

A fatal case of enoxaparin induced skin necrosis and thrombophilia.

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Department of Hematology and Bone Marrow Transplantation, Thrombosis and Hemostasis Unit, Rambam Medical Centre and Bruce Rappaport Faculty of Medicine, Haifa, Israel.


Skin necrosis caused by heparins is a rare complication. We report a case of a 71-yr-old white woman who developed painful diffuse skin lesions, most probably related to enoxaparin treatment. Other causes of skin necrosis, including heparin induced thrombocytopenia, disseminated intravascular coagulation, protein C/protein S deficiencies, anti-phospholipid antibodies, and vitamin K deficiency were less likely in this case. The concomitant combined thrombophilia possibly aggravated the patient's clinical presentation.

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