Format

Send to

Choose Destination
Biochem Soc Trans. 2006 Aug;34(Pt 4):523-5.

Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation.

Author information

1
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Box 97, New York, NY 10021, USA. s-keeney@ski.mskcc.org

Abstract

Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.

PMID:
16856850
DOI:
10.1042/BST0340523
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center