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Pediatr Blood Cancer. 2008 Feb;50(2):381-3.

Precursor B-cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis.

Author information

1
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome which can be an inherited congenital disorder or can develop secondary to malignancy, infection, or autoimmune disease. Secondary HLH due to malignancy occurs most commonly with T or NK-cell lymphoid neoplasms. HLH with B-cell malignancies is less common and HLH has rarely been described in association with precursor B-cell acute lymphoblastic leukemia (B-ALL). We report three cases of HLH associated with B-ALL and review 17 cases of ALL-associated HLH previously reported in the literature.

PMID:
16856156
DOI:
10.1002/pbc.20950
[Indexed for MEDLINE]

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