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Internist (Berl). 2006 Sep;47(9):908, 910-2, 914-6.

[Antibiotic therapy for exacerbation].

[Article in German]

Author information

1
Medizinische Klinik III, Universit├Ątsklinikum Schleswig-Holstein - Campus L├╝beck. klaus.dalhoff@uni-luebeck.de

Abstract

Bacterial infections are involved in approximately 50% of acute exacerbations of chronic bronchitis (AECB). Pneumococci, Haemophilus influenzae and Moraxella catarrhalis are the main pathogens. Studies using quantitative cultures and molecular typing suggest a causal relationship between bacterial infection and exacerbation. Furthermore, an association between infection and bronchial inflammation has been demonstrated. In contrast to steroid therapy and non-invasive ventilation, the benefits of antibiotic treatment are not well established. Current guidelines recommend antimicrobial therapy for AECB in type I exacerbations, for patients needing ventilatory support and for patients with cardiac comorbidity. Bacterial eradication is able to prolong the infection free interval.

PMID:
16855849
DOI:
10.1007/s00108-006-1687-7
[Indexed for MEDLINE]
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