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Nat Immunol. 2006 Aug;7(8):811-7.

TLR gateways to CD1 function.

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Division of Rheumatology, Immunology & Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.


CD1-restricted T cells can be activated by diverse lipids derived from mammals, bacteria and protozoa. Certain lipids function as antigens, which bind to CD1 proteins and contact T cell antigen receptors. Other lipids activate CD1-restricted T cells by functioning as adjuvants. By stimulating Toll-like receptors on antigen-presenting cells, these adjuvants alter cytokine secretion, lipid antigen synthesis and CD1 protein translation. Delineation of the separate mechanisms by which adjuvants and antigens activate CD1-restricted T cells is leading to new hypotheses about the functions of individual CD1 proteins during the transition from innate to acquired immune responses.

[Indexed for MEDLINE]

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