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Nat Immunol. 2006 Aug;7(8):803-9.

The kinetic-segregation model: TCR triggering and beyond.

Author information

1
Nuffield Department of Clinical Medicine, The University of Oxford, and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK. simon.davis@ndm.ox.ac.uk

Abstract

How the T cell receptor engages antigen is known, but not how that 'triggers' intracellular signaling. The first direct support for a mechanism based on the spatial reorganization of signaling proteins, proposed 10 years ago and referred to as the 'kinetic-segregation' model, is now beginning to emerge, along with indications that it may also apply to the triggering of nonclonotypic receptors. We describe here the development of the model, review new data and suggest how the model fits a broader conceptual framework for receptor triggering. We also consider the capacity of the model, versus that of other proposals, to account for the established features of TCR triggering.

PMID:
16855606
DOI:
10.1038/ni1369
[Indexed for MEDLINE]

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