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J Clin Psychopharmacol. 2006 Aug;26(4):373-8.

Modafinil for atypical depression: effects of open-label and double-blind discontinuation treatment.

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1
Duke University Medical Center, Durham, NC 27710, USA.

Erratum in

  • J Clin Psychopharmacol. 2006 Oct;26(5):523.

Abstract

Atypical depression, with features of hypersomnia, hyperphagia, anergia, and rejection sensitivity, is a common presentation of major depressive disorder. There are few available effective therapies for this disorder. We test modafinil, a novel wake-promoting agent, as monotherapy for atypical depression in a double-blind, placebo-controlled, relapse prevention trial after open-label treatment. We found that modafinil significantly improved atypical depression symptoms during 12 weeks of open-label treatment (mean +/- SD Hamilton Depression Scale (29-item version) score changed from 34 +/- 8.2 at baseline to 9.7 +/- 9.3, P < 0.0001), and that benefits were maintained alike in both the continuation and placebo arms during the double-blind treatment phase (P = 0.92). Modafinil was well tolerated and the drug was associated with significant weight loss compared with placebo (P = 0.01).

[Indexed for MEDLINE]

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