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Clin Neurophysiol. 2006 Sep;117(9):1949-56. Epub 2006 Jul 18.

Abnormalities in central auditory maturation in children with language-based learning problems.

Author information

1
The University of Texas at Dallas, School of Behavioral and Brain Sciences, Callier Advanced Hearing Research Center, 1966 Inwood Rd., Dallas, TX 75206, USA. pgilley@utdallas.edu

Abstract

OBJECTIVE:

To examine maturation of the central auditory pathways in children with language-based learning problems (LP).

METHODS:

Cortical auditory evoked potentials (CAEPs) recorded from 26 children with LP were compared to CAEPs recorded from 38 typical children. CAEP responses were recorded in response to a speech sound, /uh/, which was presented in a stimulus train with decreasing inter-stimulus intervals (ISIs) of 2000, 1000, 560, and 360 ms.

RESULTS:

We identified three atypical morphological categories of CAEP responses in the LP group. Category 1 responses revealed delayed P1 latencies and absent N1/P2 components. Category 2 responses revealed typical P1 responses, but delayed N1 and P2 responses. Category 3 responses revealed generally low-amplitude CAEP responses. A fourth sub-group of LP children had normal CAEP responses.

CONCLUSIONS:

Overall, the majority of children with LP had abnormal CAEP responses. These children fell into distinct categories based on the abnormalities in maturational patterns of their CAEP responses.

SIGNIFICANCE:

We describe a rate sensitive stimulation paradigm which may be used to identify and categorize LP children who exhibit abnormal patterns of central auditory maturation.

PMID:
16854621
DOI:
10.1016/j.clinph.2006.05.015
[Indexed for MEDLINE]

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