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BMC Med Res Methodol. 2006 Jul 19;6:34.

Increasing recruitment to randomised trials: a review of randomised controlled trials.

Author information

  • 1York Trials Unit, Department of Health Sciences, University of York, York, YO10 5DD, UK. jmw19@york.ac.uk

Abstract

BACKGROUND:

Poor recruitment to randomised controlled trials (RCTs) is a widespread and important problem. With poor recruitment being such an important issue with respect to the conduct of randomised trials, a systematic review of controlled trials on recruitment methods was undertaken in order to identify strategies that are effective.

METHODS:

We searched the register of trials in Cochrane library from 1996 to end of 2004. We also searched Web of Science for 2004. Additional trials were identified from personal knowledge. Included studies had to use random allocation and participants had to be allocated to different methods of recruitment to a 'real' randomised trial. Trials that randomised participants to 'mock' trials and trials of recruitment to non-randomised studies (e.g., case control studies) were excluded. Information on the study design, intervention and control, and number of patients recruited was extracted by the 2 authors.

RESULTS:

We identified 14 papers describing 20 different interventions. Effective interventions included: telephone reminders; questionnaire inclusion; monetary incentives; using an 'open' rather than placebo design; and making trial materials culturally sensitive.

CONCLUSION:

Few trials have been undertaken to test interventions to improve trial recruitment. There is an urgent need for more RCTs of recruitment strategies.

PMID:
16854229
PMCID:
PMC1559709
DOI:
10.1186/1471-2288-6-34
[PubMed - indexed for MEDLINE]
Free PMC Article
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