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Arch Int Pharmacodyn Ther. 1991 Mar-Apr;310:76-86.

Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae.

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1
Department of Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.

Abstract

The alpha-adrenergic activity of a dopamine receptor agonist, 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127), has been studied on isolated rabbit and rat aortic strips. In both tissues, RDS-127 produced concentration-dependent contractions and its potency was not significantly different from that of phenylephrine. RDS-127-induced contractions were antagonized competitively by both prazosin and phentolamine in rabbit aortic strips, but the antagonists were noncompetitive in rat aortic strips.

PMID:
1685313
[Indexed for MEDLINE]
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